5-LOX-IN-6
CAS No. : 1159576-98-3
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| 5mg | $650 | Get quote |
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| Cat. No. : | HY-120502 |
| M.Wt: | 379.84 |
| Formula: | C22H18ClNO3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
5-LOX-IN-6 (compound 11a) is a direct and reversible inhibitor of 5-lipoxygenase (5-LO). 5-LOX-IN-6 inhibits 5-LO activity in human neutrophils and recombinant human 5-LO with IC50 values of 0.23 and 0.086 µM, respectively. 5-LOX-IN-6 prevents leukotriene biosynthesis. 5-LOX-IN-6 can be used for inflammatory and allergic disorders research[1].
In Vitro:5-LOX-IN-6 (compound 11a) (0-10 µM) efficiently blocks 5-LO product formation in human whole blood assays (IC50=0.83-1.6 µM)[1].
5-LOX-IN-6 (0-10 µM) fails to block A23187 (HY-N6687, 2.5 µM)-induced translocation of 5-LO in neutrophils[1].
In Vivo:5-LOX-IN-6 (compound 11a) (4 mg/kg, ip) significantly prevents leukotriene B4 production in pleural exudates of λ-carrageenan (HY-N9470)-treated rats, associated with reduced severity of pleurisy[1].
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