BML-280
CAS No. : 1158347-73-9
(Synonyms: VU0285655-1)
| Size | Price | Stock |
|---|---|---|
| 5mg | $230 | In-stock |
| 10mg | $380 | In-stock |
| 25mg | $790 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-114095 |
| M.Wt: | 429.51 |
| Formula: | C25H27N5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
BML-280 (VU0285655-1) is a potent and selective phospholipase D2 (PLD2) inhibitor. BML-280 has the ability to prevent caspase-3 cleavage and reduction in cell viability induced by high glucose. BML-280 can be used for rheumatoid arthritis research[1][2].
In Vitro: BML-280 shows an approximately 21-fold selectivity for PLD2[3].
BML-280 (0-0.1 µM) suppresses formyl-Met-Leu-Phe (fMLP)-stimulated PLD activity in a concentration dependent manner, with an IC50 of 0.04 ± 0.01 μM[3].
BML-280 (0-0.3 µM) inhibits O2- generation, and the inhibition reaches a plateau (about 20 % inhibition) at around 0.01 μM to 0.3 μM[3].
BML-280 (0-5 µM, 24 h) reduces proliferation in PLD1-deficient cells, but also in PLD2-deficient cells exposed to IGF-1 (Insulin-like growth factor 1)[1].
BML-280 inhibits mRNA levels and secretion of tumor necrosis factor-α, IL-1β and IL-8 in human periodontal ligament cells[2].
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