DC07090 (dihydrochloride)
CAS No. : 1158264-37-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $165 | In-stock |
| 10mg | $270 | In-stock |
| 25mg | $545 | In-stock |
| 50mg | $875 | In-stock |
| 100mg | $1400 | In-stock |
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| Cat. No. : | HY-123517 |
| M.Wt: | 375.25 |
| Formula: | C18H16Cl2N4O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
DC07090 dihydrochloride is a low toxicity, potent, reversible and competitive non-peptidyl human enterovirus 71 3C protease inhibitor with an IC50 and a Ki value for 21.72 μM and 23.29 μM. DC07090 dihydrochloride could also inhibit coxsackievirus A16 (CVA16) replication with an EC50 value of 27.76 μM[1].
IC50 & Target:IC50: 21.72 μM (EV71 3C protease)[1].
Ki: 23.29 μM (EV71 3C protease)[1].
EC50: 27.76 μM (coxsackievirus A16)[1]
In Vitro:DC07090 dihydrochloride forms stable hydrogen-bonding interactions with the main chains of S128, G145, G164 and hydrophobic interactions with F25, L125, L127 and F170. DC07090 dihydrochloride (0.01~10 μM) shows micromolar potency against EV71 3Cpro. DC07090 dihydrochloride exhibits a highly inhibitory potency on EV71 replication with an EC50 value of 22.09 μM. DC07090 dihydrochloride inhibits CVA16 with an EC50 value of 27.76 μM[1].
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