CI 972 (anhydrous)
CAS No. : 115787-68-3
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| Cat. No. : | HY-118047 |
| M.Wt: | 297.76 |
| Formula: | C11H12ClN5OS |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
CI 972 anhydrous is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (Ki=0.83 μM) under development as a T cell-selective immunosuppressive agent[1][2]. IC50 & Target: Ki: 0.83 μM (PNP)[1] In Vivo: CI 972 anhydrous (5-150 mg/kg; p.o.) produces dose-dependent elevation of plasma inosine one hour after administration to rats[1].
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