ER-819762
CAS No. : 1155773-15-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $304 | Get quote |
| 5mg | $759 | Get quote |
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| 50 mg | Get quote | |
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| Cat. No. : | HY-116099 |
| M.Wt: | 489.65 |
| Formula: | C30H39N3O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
ER-819762 is an orally active, highly selective prostaglandin E2 (PGE2) EP4 receptor antagonist with an EC50 of 70 nM against human EP4 receptor. ER-819762 can be used for rheumatoid arthritis research[1].
In Vitro: ER-819762 suppresses human EP4 receptor-mediated cell signalling as measured in a cAMP-dependent reporter assay (IC50 value of 59 ± 6 nM)[1].
ER-819762 (0-10 μM, 3 days) selectively suppresses PGE2-induced Th1 differentiation[1].
ER-819762 (0-5 μM, 24 h) suppresses IL-23 secretion in human monocyte-derived dendritic cells[1].
ER-819762 (0.1 and 1 μM, 3 days) suppresses IL-17 production and inhibits IL-23-induced Th17 expansion in activated CD4+ T cells[1].
In Vivo: ER-819762 (0-100 mg/kg; p.o.; daily) suppresses inflammatory arthritis in mice[1].
ER-819762 (0-100 mg/kg; p.o.; once) suppresses CFA (Freund’s adjuvant)-induced hyperalgesia in rat[1].
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