Plazomicin
CAS No. : 1154757-24-0
(Synonyms: ACHN 490)
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| Cat. No. : | HY-16955 |
| M.Wt: | 592.68 |
| Formula: | C25H48N6O10 |
| Purity: | >98 % |
| Solubility: |
Plazomicin (ACHN 490) is a semi-synthetic aminoglycoside Antibiotic. Plazomicin acts as a substrate for Aminoglycoside acetyltransferase and Aminoglycoside phosphotransferase. Plazomicin is not modified by various common aminoglycoside-modifying enzymes. Plazomicin selectively inhibits MATE2-K. Plazomicin exhibits activity against multidrug-resistant bacteria, including carbapenem-resistant Enterobacterales[1][2].
In Vitro:Plazomicin exhibits MIC50/90 = 0.25-0.5 μg/mL/0.5-1 μg/mL Against Klebsiella, Escherichia, Enterobacter, Serratia, and Citrobacter species[1].
Plazomicin selectively inhibits MATE2-K and to a lesser extent MATE1, and OCT2, which are important transporters involved with tubular secretion[1].
Plazomicin (18 h) retains antibacterial activity against most aminoglycoside modifying enzyme-expressing E. coli BW25113 and E. coli BW25113 ΔbamB ΔtolC strains[2].
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