IOX4
CAS No. : 1154097-71-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $61 | In-stock |
| 10mg | $116 | In-stock |
| 25mg | $270 | In-stock |
| 50mg | $462 | In-stock |
| 100mg | $787 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-120110 |
| M.Wt: | 328.33 |
| Formula: | C15H16N6O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
IOX4 is a selective HIF prolyl-hydroxylase 2 (PHD2) inhibitor with an IC50 value of 1.6 nM, induces HIFα in cells and in wildtype mice with marked induction in the brain tissue. IOX4 competes with and displaces 2-oxoglutarate (2OG) at the active site of PHD2[1]. IC50 & Target: IC50: 1.6 nM (PHD2)[1] In Vitro: IOX4 (1-100 μM; 5 hours) determines the EC50s for HIF1α induction are 114 μM, 86 μM and 49.5 μM in MCF-7, Hep3B and U2OS, respectively[1].
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