Tallimustine
CAS No. : 115308-98-0
(Synonyms: FCE 24517)
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| Cat. No. : | HY-105270 |
| M.Wt: | 697.61 |
| Formula: | C32H38Cl2N10O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Tallimustine (FCE 24517), a distamycin-A derivative, is an anticancer agent[1][2][4].
In Vitro:Tallimustine (0.1-10 μM, 4 h) induces damage to purified SV40 DNA[1].
Tallimustine (72 h ) shows cytotoxicity in CEM Cells, with an IC50 of 3.5 nM[1].
Tallimustine (25 and 100 nM, 6 days) induces erythroid differentiation of K562 cells[2].
Tallimustine (100 nM, 6 days) increases accumulation of γ-globin mRNA in K562 cells[2].
Tallimustine (0.5 μg/mL, 1 h) arrests SW626 cells in G2/M phase[3].
In Vivo:Tallimustine (3 mg/kg, i.p.) shows antileukaemic activity in L1210 tumor bearing mice[4].
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