Dofetilide
CAS No. : 115256-11-6
(Synonyms: UK 68789)
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $79 | In-stock |
| 25mg | $142 | In-stock |
| 50mg | $220 | In-stock |
| 100mg | $315 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-B0232 |
| M.Wt: | 441.56 |
| Formula: | C19H27N3O5S2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Dofetilide (UK 68789), as a class III antiarrhythmic agent, is an orally active, potent and specific IKr blocker. Dofetilide can be used for the research of cardiovascular disease[1][2].
IC50 & Target: IKr[1]
In Vivo: Dofetilide (3~100 μg/kg; i.v.) increases repolarisation time via a selective prolongation of activation repolarisation interval, activation time being unchanged[2].
Dofetilide is metabolized by CYP3A4 to a mixture of inactive polar metabolites that are then excreted by the kidney[1].
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