Luseogliflozin (hydrate)
CAS No. : 1152425-66-5
(Synonyms: TS 071 (hydrate))
| Size | Price | Stock |
|---|---|---|
| 1mg | $490 | In-stock |
| 5mg | $1225 | In-stock |
| 10mg | $1960 | In-stock |
| 25mg | $3955 | In-stock |
| 50mg | $6300 | In-stock |
| 100mg | $9800 | Get quote |
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| Cat. No. : | HY-10449A |
| M.Wt: | 452.56 |
| Formula: | C23H32O7S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Luseogliflozin (TS 071) hydrate is a selective potent and orally active second-generation sodium-glucose co-transporter 2 (SGLT2) inhibitor with an IC50 of 2.26 nM. Luseogliflozin hydrate can be used for the research of type 2 diabetes mellitus (T2DM)[1][2]. IC50 & Target:IC50: 2.26 nM (SGLT2)[1][2] In Vitro: Luseogliflozin can increase beta cell proliferation through the activation of the FoxM1/PLK1/CENP-A pathway via humoral factors thats act in an insulin/IGF-1 receptor-independent manner. Luseogliflozin increases beta cell proliferation in OSI-906-treated mice[2]. In Vivo: SGLT2 inhibition with Luseogliflozin (10 mg/kg/daily; oral gavage) significantly ameliorates hyperglycaemia, but not hyperinsulinaemia, in the OSI-906(45 mg/kg)-treated mice. Luseogliflozin ameliorates hyperglycaemia induced by OSI-906[2].
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