Antagonist G
CAS No. : 115150-59-9
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| 10mg | $290 | In-stock |
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| Cat. No. : | HY-P1185 |
| M.Wt: | 951.19 |
| Formula: | C49H66N12O6S |
| Purity: | >98 % |
| Solubility: | H2O : 50 mg/mL (ultrasonic) |
Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy[1][2].
In Vitro: Antagonist G (0-100 μM) induces apoptosis is redox-sensitive and caspase-dependently in SCLC cells[2].
Antagonist G activates JNK1 in SCLC cells[2].
Antagonist G is not intrinsically a free radical oxygen donor but stimulates free radical generation specifically within SCLC cells (6.2-fold) and increases the activity of the redox-sensitive transcription factor AP-1 by 61%[2].
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