CNQX


CAS No. : 115066-14-3

(Synonyms: FG9065)

115066-14-3
Price and Availability of CAS No. : 115066-14-3
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5mg $50 In-stock
10mg $70 In-stock
25mg $150 In-stock
50mg $240 In-stock
100mg $380 In-stock
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Cat. No. : HY-15066
M.Wt: 232.15
Formula: C9H4N4O4
Purity: >98 %
Solubility: H2O : 1 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : 20 mg/mL (ultrasonic)
Introduction of 115066-14-3 :

CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist[1]. CNQX blocks the expression of fear-potentiated startle in rats[5]. IC50 & Target: IC50: 0.3 μM (AMPA) and 1.5 μM (kainate receptor)[1] In Vitro: CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices[2].
CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments[3].
In Vivo: CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices[2].
CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments[3].

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