ITK antagonist
CAS No. : 1149753-56-9
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| Cat. No. : | HY-13232 |
| M.Wt: | 494.65 |
| Formula: | C26H34N6O2S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
ITK antagonist (compound 10 n) is a potent, orally active and selective ITK (Interleukin-2 inducible T-cell kinase) antagonist (IC50=1 and 20 nM in different assays). ITK antagonist inhibits insulin receptor kinase (IRK) with an IC50 of 160 nM[1]. In Vitro: ITK antagonist inhibits DT40 cell (IC50=4 nM) and shows IL-2 inhibition (IC50=20 nM)[1].
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