MK-3901
CAS No. : 1149750-69-5
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| Cat. No. : | HY-122163 |
| M.Wt: | 481.53 |
| Formula: | C28H24FN5O2 |
| Purity: | >98 % |
| Solubility: |
MK-3901 is a selective P2X3 receptor antagonist with an IC50 of 24 nM. MK-3901 inhibits UGT1A1 (with an IC50 of 1 μM) and CYP2C9 (with an IC50 of 5.7 μM). MK-3901 activates PXR. MK-3901 induces hyperbilirubinemia. MK-3901 can be used for the research of inflammatory pain[1].
In Vitro:MK-3901 potently antagonizes the P2X3 receptor in a cell-based patch clamp electrophysiology assay with an IC50 of 24 nM[1].
MK-3901 inhibits UGT1A1 enzyme activity in a cell-free biochemical assay with an IC50 of 1 μM[1].
MK-3901 inhibits CYP2C9 enzyme activity in a human liver microsome-based cell-free biochemical assay with an IC50 of 5.7 μM[1].
MK-3901 (10 μM) activates the pregnane X receptor (PXR) by 47%[1].
In Vivo:MK-3901 is demonstrated to induce hyperbilirubinemia in multiple species in preclinical studies[1].
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