Ciwujianoside B

Ciwujianoside B is an orally active, blood-brain barrier penetrable radioprotective agent and memory enhancer. Ciwujianoside B reduces radiation-induced DNA damage, cell cycle arrest and apoptosis, downregulates NF-κB and the Bax/Bcl-2 ratio, and enhances the proliferative capacity of bone marrow cells. Ciwujianoside B enhances object recognition memory in normal mice and induces dendritic extension in primary cultured cortical neurons. Ciwujianoside B can be used in studies related to hematopoietic system radiation injury and memory enhancement^[1][2]. In Vitro:Ciwujianoside B (1-10 μM; 4 days) significantly enhances dendrite growth in primary cultured mouse cortical neurons^[2]. In Vivo:Ciwujianoside B (10-80 mg/kg; intragastric administration; once daily; for 7 consecutive days) alleviates hematopoietic injury in mice: it prolongs median survival time, reduces bone marrow cell apoptosis, decreases lymphocyte DNA damage, and simultaneously restores normal bone marrow cell cycle distribution and Bax/Bcl-2 ratio^[1].
Ciwujianoside B (0.5 mg/kg; p.o.; administered daily for 17 consecutive days) significantly enhances object recognition memory in 8-week-old male ddY mice^[2].