Carbobenzoxyproline


CAS No. : 1148-11-4

(Synonyms: L-Cbz-Proline)

1148-11-4
Price and Availability of CAS No. : 1148-11-4
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Cat. No. : HY-Y0588
M.Wt: 249.27
Formula: C13H15NO4
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 1148-11-4 :

Carbobenzoxyproline (L-Cbz-Proline) is an inhibitor of prolidase. Carbobenzoxyproline can be used for prolidase deficiency (PD) research[1]. In Vitro:Carbobenzoxyproline (6 mM; 0-10 d; pH=6.0) causes mitochondrial depolarization and increases cellular death by 33% as reported for long-term culture of fibroblasts from prolidase deficiency (PD) patients[1].
Carbobenzoxyproline (0, 1, 3, 6 mM; 1 min; pH=6.0) results fibroblasts prolidase (FBP) hydrolysis, shows linear competitive inhibition[1].
In Vivo:Carbobenzoxyproline (60 mg/kg; injection; once daily; 3 weeks) serves as in vivo inhibitor of erythrocytes prolidase in mice model[1].

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