Fascaplysin
CAS No. : 114719-57-2
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|---|---|---|
| 5mg | $454 | In-stock |
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| Cat. No. : | HY-112328 |
| M.Wt: | 306.75 |
| Formula: | C18H11ClN2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity[1][2].
In Vitro: Fascaplysin induces autophagy as a cytoprotective response via ROS and p8 in vascular endothelial cells (VECs)[2].
Fascaplysin targets metabolic activity of the prostate cancer cells, without disrupting cell membrane's integrity[2].
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Fascaplysin induces caspase mediated crosstalk between apoptosis and autophagy through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells[2].
In Vivo: Fascaplysin suppresses the growth of S180 cell-implanted tumors in vivo[2]
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