SNS-314 (mesylate)
CAS No. : 1146618-41-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $70 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $220 | In-stock |
| 50mg | $320 | In-stock |
| 100mg | $500 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12003 |
| M.Wt: | 527.04 |
| Formula: | C19H19ClN6O4S3 |
| Purity: | >98 % |
| Solubility: | DMSO : 150 mg/mL (ultrasonic) |
SNS-314 mesylate is a potent and selective aurora kinase inhibitor with IC50s of 9, 31, and 6 nM for aurora A, B and C, respectively[1]. IC50 & Target: IC50: 9 nM (Aurora A), 31 nM (Aurora B), 6 nM (Aurora C)[1] In Vitro: SNS-314 blocks proliferation in a broad panel of tumor cell lines (HCT116, A2780, PC-3, HeLa, MDA-MB-231, H-1299, and HT29) with IC50 values ranging from 1.8 nM in A2780 ovarian cancer cells to 24 nM in HT29 colon cancer cells[2]. In Vivo: In the HCT116 human colon cancer xenograft model, administration of 50 and 100 mg/kg SNS-314 leads to dose-dependent inhibition of histone H3 phosphorylation for at least 10 h. SNS-314 shows significant tumor growth inhibition in a dose dependent manner under a variety of dosing schedules including weekly, bi-weekly, and 5 days on/9 days off[2].
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