FK 973
CAS No. : 114580-45-9
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| Cat. No. : | HY-106109 |
| M.Wt: | 447.40 |
| Formula: | C20H21N3O9 |
| Purity: | >98 % |
| Solubility: |
FK 973 is a dihydrobenzoxazine anticancer agent. FK 973 selectively inhibits DNA synthesis and can form DNA cross-links through cytoplasmic activation. FK 973 exhibits significant antitumor activity in various animal tumor models and human tumor xenografts, with relatively weak myelosuppressive effects. FK 973 is sensitive to neural tumor cells. FK 973 can be used for DNA-targeted antitumor research[1][2].
In Vitro:FK 973 (48 h) inhibits cancer cells growth including human glioblastoma (ONS-6, 12, 23, and ONS-12/ACNU), human medulloblastoma (ONS-76, 81), human neuroblastoma (ST), murine glioblastoma (RSV-M glioma) and L1210 cells with IC50s of 0.06-5 μg/mL[1][2].
FK 973 (0-30 μM, 1 h) forms DNA-DNA interchain cross-links and DNA-protein cross-links without causing DNA single-strand breaks in L1210 cells[2].
In Vivo:FK 973 (intrathecal, i.t.) significantly prolongs the survival of mice in a meningioma model[1].
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