PQCA
CAS No. : 1144504-35-7
| Size | Price | Stock |
|---|---|---|
| 1mg | $95 | In-stock |
| 5mg | $235 | In-stock |
| 10mg | $404 | In-stock |
| 25mg | $641 | In-stock |
| 50mg | $886 | In-stock |
| 100mg | $1177 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-118342 |
| M.Wt: | 388.42 |
| Formula: | C22H20N4O3 |
| Purity: | >98 % |
| Solubility: | Methanol : 50 mg/mL (ultrasonic;adjust pH to 11 with NaOH);DMSO : 10 mg/mL (ultrasonic;warming;heat to 80°C) |
PQCA is a highly selective and potent muscarinic M1 receptor positive allosteric modulator. PQCA has an EC50 value of 49 nM and 135 nM on rhesus and human M1 receptor, respectively. PQCA is inactive for other muscarinic receptors. PQCA has potential to reduce the cognitive deficits associated with Alzheimer's disease[1][2]. IC50 & Target: EC50: 49 nM (Rhesus M1 receptor) and 135 nM (Human M1 receptor)[1] In Vivo: PQCA (3-30 mg/kg; oral administration; single- or pair-housed male rhesus monkeys) treatment attenuates the scopolamine deficits in PAL and CPT tasks. Blockade of muscarinic signaling by scopolamine produces significant impairments in both tasks[1].
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