CWP232228
CAS No. : 1144044-02-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $285 | In-stock |
| 5mg | $600 | In-stock |
| 10mg | $900 | In-stock |
| 25mg | $1710 | In-stock |
| 50mg | $2565 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-18959 |
| M.Wt: | 717.62 |
| Formula: | C33H34N7Na2O7P |
| Purity: | >98 % |
| Solubility: |
CWP232228, a highly potent selective Wnt/β-catenin signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 suppresses tumor formation and metastasis without toxicity through the inhibition of the growth of breast and liver cancer stem cells (CSCs)[1].
IC50 & Target:Wnt/β-catenin[1]
In Vitro:CWP232228 (0.01-100 μM; 48 hours) inhibits cell proliferation with IC50 values are 2 and 0.8 μM in mouse (4T1) and human (MDA-MB-435) breast cancer cell lines, respectively[1].
CWP232228 (0.01-10 μM; 48 hours) inhibits cell proliferation with IC50s of 2.566, 2.630, and 2.596 μM in Hep3B, Huh7 and HepG2 cells, respectively[2].
In Vivo:CWP232228 (100 mg/kg, administered i.p.; daily; 21days for mice bearing 4T1 cell tumors; 60 days for mice bearing MDA-MB-435 cell tumors) results in a significant reduction in tumor volume[1].
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