AM-1638
CAS No. : 1142214-62-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $300 | In-stock |
| 10mg | $480 | In-stock |
| 25mg | $960 | In-stock |
| 50mg | $1400 | In-stock |
| 100mg | $2100 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-13467 |
| M.Wt: | 514.63 |
| Formula: | C33H35FO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
AM-1638 is an orally active full agonist of GPR40 (EC50: 0.16 μM). AM-1638 increases the expression of antioxidant molecules (HO-1 and NQO-1). AM1638 blocks Palmitate (HY-N0830)-mediated superoxide production and ER stress. AM-1638 has antidiabetic activity and improves glycemic control in BDF mice with diet-induced obesity (DIO). AM-1638 demonstrates excellent oral bioavailability (mouse, >100%; rat, 72%; and cyno, 71%)[1][2][3]. IC50 & Target:IC50: 0.16 μM (GPR40/FFA1)[1] In Vivo:AM-1638 exhibits moderate cross-species plasma clearance and volume of distribution, resulting in plasma half-lives suitable for evaluation of its antidiabetic properties in mouse, rat, and cynomologus monkey. Moreover, oral administration of full agonist AM-1638 demonstrates excellent oral bioavailability (mouse, >100%; rat, 72%; and cyno, 71%). AM-1638 exhibits antidiabetic activity in BDF/DIO mice[1].
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