GSK2256294A
CAS No. : 1142090-23-0
(Synonyms: GSK 2256294)
| Size | Price | Stock |
|---|---|---|
| 1mg | $125 | In-stock |
| 5mg | $264 | In-stock |
| 10mg | $420 | In-stock |
| 50mg | $840 | In-stock |
| 100mg | $1110 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-19644 |
| M.Wt: | 447.46 |
| Formula: | C21H24F3N7O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 47 mg/mL |
GSK2256294A (GSK 2256294) is a selective and orally active inhibitor of soluble epoxide hydrolase (sEH). GSK2256294A inhibits recombinant human sEH, rat sEH orthologs and murine sEH orthologs with IC50s of 27, 61 and 189 pM, respectively. GSK2256294A can be used for the research of chronic obstructive pulmonary disease (COPD) and cardiovascular disease[1]. IC50 & Target: IC50: 27 pM (recombinant human sEH), 61 pM (rat sEH orthologs), 189 pM (murine sEH orthologs)[1] In Vitro: GSK2256294A (300 pM-10 μM; 2 h) inhibits the conversion of 14,15-EET-d11 to 14,15-DHET-d11 in human, rat and mouse whole blood[1]. In Vivo: GSK2256294A (5-30 mg/kg; p.o. twice daily 5 days/week for two weeks) inhibits the generation and maintenance of pulmonary inflammation in cigarette smoke-exposed mice[1]. GSK2256294A (30 mg/kg; p.o. twice daily for 8 days) decreases pulmonary inflammation in cigarette smoke-exposed mice[1].
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