PAOPA
CAS No. : 114200-31-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $450 | In-stock |
| 10mg | $740 | In-stock |
| 25mg | $1560 | In-stock |
| 50mg | $2500 | In-stock |
| 100mg | $3500 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-103423 |
| M.Wt: | 254.29 |
| Formula: | C11H18N4O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
PAOPA, an analog of L-proline-l-leucine-glycine amide (PLG) peptide, is an allosteric modulator of Dopamine D2 Receptor. PAOPA can effectively reduce behavioral abnormalities in rodent models of schizophrenia. PAOPA increases the high affinity dopamine D2 receptor and promotes its binding to agonists[1].
In Vitro: PAOPA (10 μM; 1.5 h) increases the expression of GRK2 striatum, arrestin-3, phosphorylated ERK1 and ERK2 in D2/eYFP. Cells[1].
PAOPA (10 μM; 48 h) promotes the internalization of D2 receptors in D2/eYFP. Cells[1].
In Vivo: PAOPA (1 mg/kg; 腹腔注射; 每天 1 次, 共 45 天) 慢性给药, 引起小鼠体内 D2 受体调节和下游分子 (包括 GRK2、arrestin-3 和细胞外受体激酶 ERK 1/2) 的表达增加[1].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- PAOPA
- Cat. No.:
- HY-103423
- Quantity:
Your information is safe with us.