PVZB1194
CAS No. : 1141768-04-8
| Size | Price | Stock |
|---|---|---|
| 10mg | $50 | In-stock |
| 25mg | $110 | In-stock |
| 50mg | $180 | In-stock |
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| Cat. No. : | HY-122247 |
| M.Wt: | 319.27 |
| Formula: | C13H9F4NO2S |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
PVZB1194 is a biphenyl-type inhibitor of Kinesin-5 ATPase activity that binds to the α4/α6 site of the motor domain in a nucleotide competitive manner. PVZB1194 has an IC50 of 0.12 μM for KSP ATPase. PVZB1194 induces mitotic arrest with the formation of a monopolar spindle, and inhibits HeLa cells proliferatio (IC50: 5.5 μM). PVZB1194 can be used in the study of tumors[1][2]. IC50 & Target:IC50: 0.12 μM (KSP ATPase)[2] In Vitro:PVZB1194 (1-5 nM; 24-72 h) inhibits cell proliferation and induces mitotic arrest in a concentration-dependent manner in HeLa cells[1].
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