Cedazuridine
CAS No. : 1141397-80-9
(Synonyms: E7727)
| Size | Price | Stock |
|---|---|---|
| 1mg | $65 | In-stock |
| 5mg | $135 | In-stock |
| 10mg | $216 | In-stock |
| 25mg | $388 | In-stock |
| 50mg | $582 | In-stock |
| 100mg | $873 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-109081 |
| M.Wt: | 268.21 |
| Formula: | C9H14F2N2O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C) |
Cedazuridine (E7727) (Compound 7a) is an orally active cytidine deaminase (CDA) inhibitor with an IC50 value of 0.4 μM. Cedazuridine can be used for cancer research[1].
IC50 & Target:IC50: 0.4 μM (CDA)[1]
In Vitro: Cedazuridine (Compound 7a) exhibits superior acid stability[1].
Cedazuridine (0-10 μM; 72 h) does not enhance effects of AZA (5-Azacytidine, HY-10586) in growth inhibition of AML cell lines[2].
In Vivo: Cedazuridine (3 mg/kg; p.o.; daily for 7 days) in combination with 2.5 mg/kg AZA shows tumor regression in mice MOLM-13 CDX and PDX models[2].
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