Phaclofen
CAS No. : 114012-12-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $220 | In-stock |
| 10mg | $375 | In-stock |
| 25mg | $830 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-100798 |
| M.Wt: | 249.63 |
| Formula: | C9H13ClNO3P |
| Purity: | >98 % |
| Solubility: | 1M NaOH : 50 mg/mL (ultrasonic);DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) |
Phaclofen is a selective GABAB receptor antagonist. Phaclofen is a peripheral and central baclofen antagonist. Phaclofen maybe a potential compound in determining the physiological significance of central and peripheral bicuculline-insensitive receptors with which GABA and (-)-baclofen interact[1][2].
IC50 & Target: GABAB receptor[1]
In Vitro: The GABAB antagonist phaclofen (500 µM) partly prevents the effect of 1 µM of (R＋) baclofen[5].
In Vivo: Phaclofen (2 mg/kg; i.p) shows that fewer neuropeptide Y-like immunoreactive fibers are detected in the stimulated cuneate nucleus[4].
Phaclofen (2 mg/kg; s.c) antagonizes the effects of 6 mg/kg R(＋) baclofen in dorsal striatum[5].
Phaclofen (100 nmol; intrathecal injection) antagonizes the depressant effect of baclofen. Phaclofen (100 nmol) is devoid of stimulatory or depressant effects on spinal reflexes[3].
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