Neostigmine (Bromide)
CAS No. : 114-80-7
(Synonyms: Eustigmin bromide; Neoserine bromide)
Price and Availability of
CAS No. : 114-80-7
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|---|---|---|
| 100mg | $60 | In-stock |
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| Cat. No. : | HY-B0423 |
| M.Wt: | 303.20 |
| Formula: | C12H19BrN2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 100 mg/mL (ultrasonic) |
Introduction of
114-80-7
:
Neostigmine (Eustigmin) Bromide is an orally active and reversible cholinesterase inhibitor that acts on myasthenia gravis to prolong and intensify the muscarinic and nicotinic effects of acetylcholine. Neostigmine Bromide can be used in anesthesia to reverse the neuromuscular blockade produced by competitive neuromuscular blockers[1][2][3][4].
In Vivo:
Pharmacokinetic parameters of oral tablet and nasal microspheres of Neostigmine Bromide in rabbits[1]
| Formulation | Tmax (h) | Cmax (ng/mL) | AUC (ng·h/mL) | Kel (h-1) | T1/2 (h) |
| Oral | 1.5 | 60.07 | 94.17 | 0.582 | 1.19 |
| IN1 | 3 | 95.51 | 446.25 | 0.164 | 4.22 |
| IN2 | 3 | 90.32 | 406.85 | 0.196 | 3.53 |