GSK-3β inhibitor 8
CAS No. : 1139875-74-3
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| Cat. No. : | HY-120902 |
| M.Wt: | 413.92 |
| Formula: | C20H20ClN5OS |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
GSK-3β inhibitor 8, a thiophenacil derivative, is an effective and selective inhibitor of GSK-3β (IC50=64 nM). GSK-3β inhibitor 8 negatively regulated Wnt signaling pathway and stimulated β cell proliferation[1][2].
In Vitro:GSK-3β inhibitor 8 (compound 1a) (1 nM-100 μM; 7 d) dose-dependently stimulates β-cell proliferation with an EC50 value of 1.41 μM. And GSK-3β inhibitor 8 (2 μM; 72 h) increases the replicating R7T1 β cells about 2-fold[1].
GSK-3β inhibitor 8 (1 nM-100 μM; 24 h) induces the activation of Super (8X) TOPFlash reporter with an EC50 value of 1.25 μM[1].
GSK-3β inhibitor 8 (2 μM; 72 h) stimulates the translocation of β-catenin into the nucleus in HEK293 cells[1].
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