Talotrexin
CAS No. : 113857-87-7
(Synonyms: PT523)
| Size | Price | Stock |
|---|---|---|
| 1mg | $475 | In-stock |
| 5mg | $1188 | In-stock |
| 10mg | $1900 | In-stock |
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| Cat. No. : | HY-10824 |
| M.Wt: | 573.56 |
| Formula: | C27H27N9O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Talotrexin (PT523), an analog of Aminopterin (HY-14518), is a nonpolyglutamatable classic antifolate. Talotrexin is a RFC (reduced folate carrier) specific inhibitor and selectively inhibits RFC transport. Talotrexin shows antitumor activity by targeting DHFR to inhibit tumor growth[1][2].
In Vitro: Talotrexin shows no significant PCFT or FRα inhibitory activity[1].
Talotrexin (1-1000 nM) inhibits proliferation of R1-11/Tet-on-RFC HeLa cells[2].
In Vivo: Talotrexin (0-35 mg/kg, IV injection, once weekly for 4 weeks) alone or combined with Paclitaxel (HY-B0015, 7.5 mg/kg) inhibits A549 tumor growth in mice[2].
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