Orbifloxacin
CAS No. : 113617-63-3
(Synonyms: CP-104354)
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| 100mg | $40 | In-stock |
| 200mg | $64 | In-stock |
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| Cat. No. : | HY-B0915 |
| M.Wt: | 395.38 |
| Formula: | C19H20F3N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 6 mg/mL (ultrasonic;warming) |
Orbifloxacin is an orally administrable Antibiotic. Orbifloxacin disrupts the replication and proliferation of Bacterial DNA, inhibits bacterial growth and exerts bactericidal activity. Orbifloxacin inhibits the growth of canine-derived E. coli and Pseudomonas aeruginosa isolates. Orbifloxacin is used in research related to bacterial infections[1][2][3][4].
In Vitro:Orbifloxacin (0.015-4.0 μg/mL; up to 7 days) inhibits the growth of Piscirickettsia salmonis LF-89 VR-1361, and its growth-inhibitory effect persists throughout the 7-day incubation period compared with the untreated control group[1].
Orbifloxacin (0.1×-4× MIC; 0-24 h) inhibits the growth of Staphylococcus aureus ATCC 29213 and ATCC 43300, with MIC values of 0.5 mg/L and 4 mg/L, respectively, and induces concentration-dependent post-antibiotic effect (PAE) and post-antibiotic sub-MIC effect (PA-SME)[2].
Orbifloxacin (at twice the MIC; 1 h) induces a post-antibiotic effect (PAE) with an average duration of 0.29 h in clinical canine isolates of E coli, and an average PAE duration of 0.37 h in clinical canine isolates of Pseudomonas aeruginosa[3].
Orbifloxacin (0.1×MIC-0.3×MIC) induces concentration-dependent PA-SMEs in canine clinical isolates of E coli (mean 0.55 to 2.03 h) and Pseudomonas aeruginosa (mean 1.04 to 2.47 h)[3].
Orbifloxacin (0.016-16 mg/L; 18 h) inhibits visible growth of clinical Staphylococcus intermedius strains isolated from canine skin and ear infections by 50% and 90% at concentrations of 0.5 mg/L and 1 mg/L, respectively[4].
Orbifloxacin (0.063-4 mg/L; 1-24 h) exhibits concentration-dependent bactericidal activity against Staphylococcus aureus ATCC 29213, and time-dependent bactericidal activity against Staphylococcus intermedius isolates from pyoderma[4].
In Vivo:Orbifloxacin (2.5-80 mg/kg; i.m.; twice daily; 24 hours) has an AUC24h/MIC ratio (R2 > 0.98) that is a strong predictor of its in vivo antibacterial efficacy against S. aureus, with targets of 33.78-37.79 h for bacteriostatic activity and 179.43-217.47 h for 3-log10 bacterial kill[2].
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