E-4031
CAS No. : 113559-13-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $77 | In-stock |
| 10mg | $130 | In-stock |
| 50mg | $514 | In-stock |
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| Cat. No. : | HY-15551 |
| M.Wt: | 474.44 |
| Formula: | C21H29Cl2N3O3S |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 50 mg/mL |
E-4031 is a selective hERG potassium channel blocker for use in class III anti-arrhythmic studies[1].
In Vitro: E-4031 (0.1-10 μM) significantly depolarises the maximum diastolic potential (MDP) and prolongs the action charge that depolarises MDP from -58.8+0.9 to -24.5±1.8 mV at 1 μM and from -58.2±2.1 to -19.6±1.8 mV at 10 μM in single SAN cells of New Zealand albinc rabbits[2].
E-4031 (0.1-10 μM) can block part of the outward current during the depolarisation step as well as the tail current (ITD) during subsequent repolarization in a dose-dependent manner, and depresses ITD by 88 % at 10 μM in single SAN cells of New Zealand albinc rabbits[2].
In Vivo: E-4031 (i.v., 50 μg/kg) reduces the net outward current of ventricular myocytes, prolongs the QT interval and activation-recovery interval (ARI) in all left ventricular (LV) layers, and increases transmural ARI dispersion in beagles[1].
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