KN-92 (phosphate)


CAS No. : 1135280-28-2

1135280-28-2
Price and Availability of CAS No. : 1135280-28-2
Size Price Stock
1mg $40 In-stock
5mg $130 In-stock
10mg $220 In-stock
25mg $370 In-stock
50mg $550 In-stock
100mg $780 In-stock
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Cat. No. : HY-15517A
M.Wt: 554.98
Formula: C24H28ClN2O7PS
Purity: >98 %
Solubility: H2O : < 0.1 mg/mL (ultrasonic);DMSO : 50 mg/mL (ultrasonic)
Introduction of 1135280-28-2 :

KN-92 phosphate is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 phosphate is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a cell-permeable, reversible and competitive CaMKII inhibitor[1][2]. In Vitro: KN-93 (5-50 μM; 24 hours) inhibits LX-2 cell growth and KN-92 (5-50μM; 24 hours) is ineffective in blocking cell growth[2].
The analysis of cell cycle regulator expression reveals that KN-93 rather than KN-92 reduced the expression of p53 and p21[2].

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