SR59230A (hydrochloride)
CAS No. : 1135278-41-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $176 | In-stock |
| 25mg | $363 | In-stock |
| 50mg | $605 | In-stock |
| 100mg | $990 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-103200 |
| M.Wt: | 361.91 |
| Formula: | C21H28ClNO2 |
| Purity: | >98 % |
| Solubility: | H2O : 2.5 mg/mL (ultrasonic);DMSO : 250 mg/mL (ultrasonic) |
SR59230A hydrochloride is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist[1] with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively[2]. IC50 & Target: IC50: 40 nM (β3 receptor), 408 nM ((β1 receptor), 648 nM (β2 receptor)[2] In Vitro: SR59230A (100 nM-50 μM; 24 hours) is able to reduce cell viability in a dose-dependent manner in Neuro-2A, BE(2)C and SK-N-BE(2) NB cell lines[3]. In Vivo: MDMA (20 mg/kg) produces a slowly developing hyperthermia, reaching a maximum increase of 1.8°C at 130 min post injection. SR59230A (0.5 mg/kg) produces a small but significant attenuation of the slowly developing hyperthermia to MDMA. SR59230A (5 mg/kg) reveals a significant and marked early hypothermic reaction to MDMA[4].
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