VU0357017 (hydrochloride)
CAS No. : 1135242-13-5
(Synonyms: CID-25010775)
| Size | Price | Stock |
|---|---|---|
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| 10mg | $110 | In-stock |
| 50mg | $320 | In-stock |
| 100mg | $470 | In-stock |
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| Cat. No. : | HY-19752A |
| M.Wt: | 369.89 |
| Formula: | C18H28ClN3O3 |
| Purity: | >98 % |
| Solubility: | H2O : 33.33 mg/mL (ultrasonic);DMSO : 25 mg/mL (ultrasonic) |
VU0357017 hydrochloride (CID-25010775) is a potent, selective and brain-penetrant allosteric agonist of M1 muscarinic acetylcholine receptor, with an EC50 of 477 nM. VU0357017 hydrochloride is highly selective for M1 and has no activity at M2-M5 up to the highest concentrations tested (30 μM). VU0357017 hydrochloride can be used for the research of Alzheimer’s disease and schizophrenia[1][2][3].
IC50 & Target: IC50: 477 nM (M1)[1]
In Vitro: VU0357017 is selective for M1 (Ki=9.91 µM) over M2-M5 mAChRs (Ki=21.4, 55.3, 35.0, and 50.0 μM, respectively) in CHO cells[1].
VU0357017 (1 nM-100 μM) induces calcium release and ERK phosphorylation in a concentration-dependent manner in CHO cells[3].
In Vivo: VU0357017 (1-10 mg/kg, i.p.) reverses scopolamine-induced disruption of the contextual fear conditioning response[2].
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