Baclofen
CAS No. : 1134-47-0
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|---|---|---|
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| 100g | $227 | In-stock |
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| Cat. No. : | HY-B0007 |
| M.Wt: | 213.66 |
| Formula: | C10H12ClNO2 |
| Purity: | >98 % |
| Solubility: | 0.1 M HCL : 10 mg/mL (ultrasonic);H2O : 2 mg/mL (ultrasonic);DMSO : 4.81 mg/mL (ultrasonic;warming;adjust pH to 4 with HCl;heat to 60°C) |
Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research[1][2][3].
In Vitro: Baclofen (1, 10 μM; 24 h) causes markedly decreased lactate dehydrogenase (LDH) activity, indicating increased cell viability in wild-type or mutant huntingtin-expressing striatal cells (HD19 or HD43). Baclofen significantly increases chymotrypsin-like proteasome activity and cell viability were in the HD43 cells[3].
In Vivo: Baclofen (i.p.; 10 μg/g; twice daily for 3 consecutive days) ameliorates motor deficits in YAC128 HD transgenic mice[3].
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