GDC-0834
CAS No. : 1133432-49-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $420 | In-stock |
| 10mg | $600 | In-stock |
| 25mg | $1200 | In-stock |
| 50mg | $1800 | In-stock |
| 100mg | $2880 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-15427 |
| M.Wt: | 596.74 |
| Formula: | C33H36N6O3S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 32 mg/mL |
GDC-0834 is an orally active selective, potent, and reversible BTK inhibitor with an IC50 of 5.9 nM. GDC-0834 demonstrates pBTK-Tyr223 inhibition in mice and rats. GDC-0834 can be used for research of rheumatoid arthritis (RA)[1][2].
IC50 & Target:IC50: 5.9 nM (BTK)[1]
In Vitro:GDC-0834 (1 h) inhibits BTK in rat splenocytes with a cellular IC50 of 6.4 nM[1].
GDC-0834 is shown to be a potent reversible inhibitor of six known aldehyde oxidase (AO) substrates with IC50 values ranging from 0.86 to 1.87 μM[2].
In Vivo:GDC-0834 (25-150 mg/kg; p.o.; single dose) dose-dependently inhibts pBTK-Tyr223 in BALB/c mice[1].
GDC-0834 (1-100 mg/kg; p.o.; b.i.d./q.d./Q2D; 16 days) dose-dependently inhibts pBTK-Tyr223 in CIA rats[1].
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