GDC-0834 (Racemate)
CAS No. : 1133432-46-8
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| 10mg | $322 | In-stock |
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| Cat. No. : | HY-15427A |
| M.Wt: | 596.74 |
| Formula: | C33H36N6O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
GDC-0834 Racemate is the racemic form of GDC-0834 (HY-15427). GDC-0834 is an orally active selective, potent, and reversible BTK inhibitor with an IC50 of 5.9 nM. GDC-0834 demonstrates pBTK-Tyr223 inhibition in mice and rats. GDC-0834 can be used for research of rheumatoid arthritis (RA)[1][2].
In Vitro:GDC-0834 (1 h) inhibits BTK in rat splenocytes with a cellular IC50 of 6.4 nM[1].
GDC-0834 is shown to be a potent reversible inhibitor of six known aldehyde oxidase (AO) substrates with IC50 values ranging from 0.86 to 1.87 μM[2].
In Vivo:GDC-0834 (25-150 mg/kg; p.o.; single dose) dose-dependently inhibts pBTK-Tyr223 in BALB/c mice[1].
GDC-0834 (1-100 mg/kg; p.o.; b.i.d./q.d./Q2D; 16 days) dose-dependently inhibts pBTK-Tyr223 in CIA rats[1].
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