(R)-Bicalutamide
CAS No. : 113299-40-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $100 | In-stock |
| 50mg | $355 | In-stock |
| 100mg | $568 | In-stock |
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| Cat. No. : | HY-108250 |
| M.Wt: | 430.37 |
| Formula: | C18H14F4N2O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
(R)-Bicalutamide is the (R)-enantiomer of Bicalutamide (HY-14249). (R)-Bicalutamide is an androgen receptor (AR) antagonist, with antineoplastic activity. (R)-Bicalutamide is widely used for the research of prostate cancer[1][2].
IC50 & Target: AR[1]
In Vitro: Bicalutamide (HY-14249) is available as a racemic mixture. The R isomer (R-bicalutamide) has an ≈30-fold higher binding affinity to the AR than the S isomer[1].
(R)-bicalutamide (0.02-20 μM) reduces naïve LNCaP cells survival in a dose-dependent manner[2].
In Vivo: (R)-Bicalutamide (10 mg/kg; i.g.; daily; for 4 days) has antitumor efficacy in VCaP xenografts mice[3].
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