FR 76830
CAS No. : 113243-75-7
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| Cat. No. : | HY-116960 |
| M.Wt: | 446.50 |
| Formula: | C25H26N4O4 |
| Purity: | >98 % |
| Solubility: |
FR 76830 is a bradycardic agent with cardiomyocyte protective effects. FR 76830 attenuates the decrease in myocardial pH during the early stage of ischemia. FR 76830 improves ATP levels during the late stage of ischemia. FR 76830 reduces heart rate in a dose-dependent manner without decreasing the rate-pressure product of the myocardium. FR 76830 exerts cardioprotective effects during ischemia and reperfusion. FR 76830 can be used for the research of myocardial ischemia-reperfusion injury[1]. In Vitro:FR 76830 (22.4-67.2 μM) exerts independent myocardial protective effects by simply slowing heart rate without reducing myocardial oxygen consumption (unchanged DP), alleviating early ischemic acidosis, delaying late ATP depletion, and promoting ATP recovery during reperfusion[1].
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