Nα,Nα-Bis(carboxymethyl)-L-lysine
CAS No. : 113231-05-3
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|---|---|---|
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| 10g | $139 | In-stock |
| 25g | $347 | In-stock |
| 100g | $1387 | In-stock |
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| Cat. No. : | HY-100047 |
| M.Wt: | 262.26 |
| Formula: | C10H18N2O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC50 of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study[1][2][3].
In Vitro:Nα,Nα-Bis(carboxymethyl)-L-lysine (59 nM) decreases the basal activity of H214A (constitutively active mutant of T2R4) by 40%[1].
Nα,Nα-Bis(carboxymethyl)-L-lysine (60 nM, 15 mins) blocks the decrease of basal activation state of Rac1 caused by quinine in HEK293T cells overexpressing T2R4 and Ga16/44, but has no effect in HEK293T control cells[2].
In Vivo:Nα,Nα-Bis(carboxymethyl)-L-lysine (10 μM) has no effect on lick responses to bitter compounds in adult C57BL6/J[3].
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