KGP94
CAS No. : 1131456-28-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $300 | In-stock |
| 10mg | $480 | In-stock |
| 25mg | $860 | In-stock |
| 50mg | $1350 | In-stock |
| 100mg | $1890 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-118762 |
| M.Wt: | 350.23 |
| Formula: | C14H12BrN3OS |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
KGP94 is a selective inhibitor of cathepsin L with an IC50 of 189 nM[1]. KGP94 inhibits migration and invasion of metastatic carcinoma and shows low cytotoxicity (GI50=26.9 µM) against various human cell lines[2].
IC50 & Target: 189 nM (cathepsin L)[1]
In Vitro: KGP94 (10 or 20 μM, 24 h) reduces expression of M2 (macrophage) markers (Arginase-1 and CD206) and cells invasion of primary bone marrow-derived macrophages or Raw264.7[3].
KGP94 (25 μM, 24 h) impairs the incasive capacities of both prostate and breat cancer cells by 53% and 88%, respectively[4].
KGP94 (25 μM, 24 h) suppresses secreted CTSL activity by 94% and 92% in PC-3ML and MDA-MB-231, repsectively[4].
In Vivo: KGP94 (i.p.; 20 mg/kg; once daily for 3 days) exhibits anti-metastatic and anti-bone resorptive efficacy in a prostate cancer bone metastasis model[5].
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