Argipressin

Argipressin (Arg8-vasopressin) binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a K_d value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1. In Vitro: Argipressin binds to the vascular arginine vasopressin receptor, V1, with a K_d value of 1.31 nM in A7r5 rat aortic smooth muscle cells. It also stimulates the intracellular release of calcium in A7r5 cells (EC₅₀=5 nM)^[1]. AVP-induced [Ca²⁺]_i signals and immunized activity against S-100 in DRG cell culture. The minimum effective concentrations of Argipressin causing [Ca²⁺]_i responses are 100 pM in non-neuronal cells in DRG culture^[2].