Dothiepin
CAS No. : 113-53-1
(Synonyms: Dosulepin; Dothep)
| Size | Price | Stock |
|---|---|---|
| 1mg | $200 | In-stock |
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| Cat. No. : | HY-12394 |
| M.Wt: | 295.44 |
| Formula: | C19H21NS |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Dothiepin (Dosulepin; Dothep) is an antidepressant agent with sedative/anxiolytic activity. Dothiepin is an inhibitor preferring of noradrenaline uptake than serotonin uptake. Dothiepin facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. Dothiepin is also an antagonist of histamine H1-receptor without cardiotoxicity. Dothiepin exhibits significant analgesic activity in psychogenic facial pain，idiopathic fibromyalgia syndrome or rheumatoid arthritis[1]. IC50 & Target:Histamine H1-receptor, Noradrenaline uptake (α1-and α2-adrenoceptors and serotonin 5HT1 and 5HT2-receptors)[1]
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