BzATP (triethylammonium)
CAS No. : 112898-15-4
(Synonyms: Benzoylbenzoyl-ATP (triethylammonium))
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| Cat. No. : | HY-18745 |
| M.Wt: | 816.58 |
| Formula: | C30H39N6O15P3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
BzATP triethylammonium acts as a P2X receptor agonist with pEC50s of 8.74, 5.26, 7.10, 7.50, 6.19, 6.31, 5.33 for P2X1, P2X2, P2X3, P2X2/3, P2X4 and P2X7, respectively[1]. BzATP triethylammonium is potent at P2X7 receptors with EC50s of 3.6 μM and 285 μM for rat P2X7 and mouse P2X7, respectively[2].
IC50 & Target:pEC50: 8.74 (P2X1), 5.26 (P2X2), 7.10 (P2X3), 6.19 (P2X2/3), 6.31 (P2X4), 5.33 (P2X7)[1]
EC50 3.6 μM (rat P2X7); 285 μM (mouse P2X7)[2]
In Vitro:BzATP (10-1000 μM; 24 h) triethylammonium promotes the proliferation and migration of U87 and U251 glioma cells[3].
[3].
In Vivo:BzATP (5 mg/kg) triethylammonium significantly promotes P2X7R expression in the intestines compared with intestines in the sham group and the control group after cecal ligation and puncture (CLP) induction[4].
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