Mosapride (citrate)
CAS No. : 112885-42-4
(Synonyms: TAK-370 citrate; AS-4370 citrate)
| Size | Price | Stock |
|---|---|---|
| 5mg | $30 | In-stock |
| 10mg | $44 | In-stock |
| 25mg | $75 | In-stock |
| 50mg | $120 | In-stock |
| 100mg | $180 | In-stock |
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| Cat. No. : | HY-B0189A |
| M.Wt: | 614.02 |
| Formula: | C27H33ClFN3O10 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Mosapride citrate is an orally active gastroenterokinetic compound. Mosapride citrate is a 5HT4 agonist. Mosapride citrate is a CYP inducer. Mosapride citrate has a concentration-dependent inhibitory effect on Kv4.3, and its IC50 value is 15.2 μM. Mosapride citrate can be used in the study of gastrointestinal diseases[1][2][3][4][5][6][7].
In Vitro:Mosapride citrate (1-100 nM) significantly increases the average amplitude of proximal and distal colon contraction, and shortens the transport time of proximal and distal colon in guinea-pig[3].
Mosapride citrate (869 ng/mL, 48 h) increases the induction ability of Cytochrome P450 (CYP1A2, 2B6 and 3A4) in human hepatocytes (HMC424, 478 and 493)[4].
In Vivo:Mosapride citrate (0.3-3 mg/kg or 30 mg/kg, p.o) promotes gastric empting rats in a dose-dependent manner. Gastric emptying was significantly inhibited when the dose was 30 mg/kg[5].
Mosapride citrate (0.5 mg/kg, p.o) can relieve NSAIDS induced ulcer by activating 5-HT4 receptor in rats[6].
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