Mosapride
CAS No. : 112885-41-3
(Synonyms: TAK-370; AS-4370)
| Size | Price | Stock |
|---|---|---|
| 5mg | $35 | In-stock |
| 10mg | $55 | In-stock |
| 25mg | $94 | In-stock |
| 50mg | $130 | In-stock |
| 100mg | $180 | In-stock |
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| Cat. No. : | HY-B0189 |
| M.Wt: | 421.89 |
| Formula: | C21H25ClFN3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 66.67 mg/mL (ultrasonic;warming;heat to 60°C) |
Mosapride is an orally active gastroenterokinetic compound. Mosapride is a 5HT4 agonist. Mosapride is a CYP inducer. Mosapride has a concentration-dependent inhibitory effect on Kv4.3, and its IC50 value is 15.2 μM. Mosapride can be used in the study of gastrointestinal diseases[1][2][3][4][5][6][7].
In Vitro:Mosapride (1-100 nM) significantly increases the average amplitude of proximal and distal colon contraction, and shortens the transport time of proximal and distal colon in guinea-pig[3].
Mosapride (869 ng/mL, 48 h) increases the induction ability of Cytochrome P450 (CYP1A2, 2B6 and 3A4) in human hepatocytes (HMC424, 478 and 493)[4].
In Vivo:Mosapride (0.3-3 mg/kg or 30 mg/kg p.o) promotes gastric empting rats in a dose-dependent manner. Gastric emptying was significantly inhibited when the dose was 30 mg/kg[5].
Mosapride (0.5 mg/kg p.o) can relieve NSAIDS induced ulcer by activating 5-HT4 receptor in rats[6].
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