24R-Calcipotriol

24R-Calcipotriol (PRI 2202; Impurity D of Calcipotriol), an isomer of Calcipotriol (HY-10001), is a synthetic vitamin D analog. 24R-Calcipotriol exhibits synergistic antiproliferative effects with low-dose cytostatics in in vitro. 24R-Calcipotriol produces tumor growth inhibition when combined with Cyclophosphamide (HY-17420) and Cisplatin (HY-17394) in mice models. 24R-Calcipotriol can increase serum calcium levels and reduce blood leukocyte counts. 24R-Calcipotriol can be used for the research of mammary cancer and Lewis lung cancer^[1][2]. In Vitro:24R-Calcipotriol (100 nM; 120 h) produces an additive antiproliferative effect on Lewis lung carcinoma (LLC) cells when combined with 1 μg/mL Cisplatin (HY-17394)^[1]. In Vivo:24R-Calcipotriol (10 μg/kg; s.c.; on days 2, 5, 7, 9, 12, 14, 16, 19 and 21) shows tumor growth inhibition when combined with Cyclophosphamide (HY-17420) in the 4T1 mammary adenocarcinoma model^[1].
24R-Calcipotriol (10 μg/kg; s.c.; on days 1, 3, 6, 8, 10, 13, 15, 17 and 20) alone does not significantly reduce LLC tumor volume, and combined with Cisplatin (HY-17394) yields a 52% TGI on day 20, while increasing serum calcium levels and reducing blood leukocyte counts^[1].