Letrozole
CAS No. : 112809-51-5
(Synonyms: CGS 20267)
| Size | Price | Stock |
|---|---|---|
| 25mg | $50 | In-stock |
| 50mg | $65 | In-stock |
| 100mg | $79 | In-stock |
| 200mg | $85 | In-stock |
| 500mg | $100 | In-stock |
| 1g | $180 | In-stock |
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| 10 g | Get quote | |
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| Cat. No. : | HY-14248 |
| M.Wt: | 285.30 |
| Formula: | C17H11N5 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Letrozole (CGS 20267) is a potent, selective, reversible and orally active non-steroidal inhibitor of aromatase, with an IC50 of 11.5 nM. Letrozole selective inhibits estrogen biosynthesis, and can be used for the research of breast cancer[1][2][3].
IC50 & Target:IC50: 11.5 nM (aromatase)[1]
In Vitro:Letrozole (0.1-100 nM; 24-96 h) significantly inhibits growth of the MCF-7 epithelial breast cancer cells in a dose- and time-dependent manner[2].
Letrozole (10 nM) significantly suppresses the stimulatory effects of testosterone on MCF-7 cell proliferation[2].
Letrozole (10 nM; 24-48 h) suppresses the levels of secreted metalloproteinases (MMP‐2 and MMP‐9) in MCF-7 cells[2].
In Vivo:Letrozole (3-300 μg/kg; oral gavage once daily for 6 weeks) exhibits anti-tumor effects in rats[3].
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