Scyliorhinin II
CAS No. : 112748-19-3
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| Cat. No. : | HY-P1588 |
| M.Wt: | 1851.09 |
| Formula: | C77H119N21O26S3 |
| Purity: | >98 % |
| Solubility: | 10 mM in H2O |
Scyliorhinin II is a selective neurokinin-3 receptor agonist, with a Ki of 2.5 nM for neurokinin-3 receptor in rat cerebral cortex. IC50 & Target:Ki: 2.5 nM (Neurokinin-3 receptor)[1] In Vitro: Scyliorhinin II is a neurokinin-3 selective tachykinin receptor, with a Ki of 2.5 nM for neurokinin-3 (NK-3) receptor in rat cerebral cortex. Scyliorhinin II has little effect on NK-1 and NK-2 receptors, with Ki (NK-1 receptor)/Ki (NK-3 receptor) and Ki (NK-2 receptor)/Ki (NK-3 receptor) of 176 and 200[1]. In Vivo: Scyliorhinin II produces potent, dose-related reciprocal hindlimb scratching about equipotently with an ED50 of 0.08 nmol via intracerebroventricularly (i.c.v.) administration in mice[2].
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